Methotrexate is a folic acid antagonist that inhibits folic acid tissue cell proliferation and reduction.

Methotrexate is indicated in:
– small cell lung cancer
– ovarian cancer
– bladder cancer
– breast cancer
– otorhinolaryngological cancers
– placental choriocarcinomas
– acute lymphoblastic leukaemias
– malignant non-Hodgkin’s lymphoma
– crohn’s diseases
– juvenile chronic polyarthritis
– rheumatoid arthritis
– widespread and severe psoriasis
– psoriatic arthritis
– bone sarcomas